Monday, April 23, 2012

Clinical signs that an environmental pollutant can contribute to obesity by prenatal exposure

Error in deserializing body of reply message for operation 'Translate'. The maximum string content length quota (8192) has been exceeded while reading XML data. This quota may be increased by changing the MaxStringContentLength property on the XmlDictionaryReaderQuotas object used when creating the XML reader. Line 1, position 9035.
Main Category: Obesity / Weight Loss / Fitness
Also Included In: Pregnancy / Obstetrics;  Pediatrics / Children's Health
Article Date: 18 Apr 2012 - 0: 00 PDT

email iconemail to a friend printer icon printer friendly write icon views

not yet ratednot yet rated
Overall, 17% of children in the United States are obese, and in inner-city neighborhoods, the prevalence is as high as 25%. While poor diets and physical inactivity are the main culprits, there is new evidence that air pollution can play a role.

A study by Columbia University's Mailman School of Public Health finds that pregnant women in New York City exposed to higher concentrations of chemicals called polycyclic aromatic hydrocarbons, or PAHs, were more than twice as likely to have children who were obese by age 7 compared with women with lower levels of exposure. PAH, a common urban pollutant, are released into the air from the burning of coal, diesel, oil and gas, or other organic substances such as tobacco.

Results are published in the American Journal of Epidemiology.

"Obesity is a complex disease with multiple risk factors." "It isn't just the result of individual choices like diet and exercise," says the study's lead author Andrew g. Rundle, Dr. P.H., a professor of epidemiology at Columbia's Mailman School of Public Health. "For many people who don't have the resources to buy healthy food or don't have the time to exercise, prenatal exposure to air pollution may tip the scales, making them even more susceptible to obesity."

Researchers recruited 702 non-smoking pregnant women through prenatal clinics at NewYork-Presbyterian Hospital and Harlem Hospital. The women were 18-35 years old, identified themselves as either African-American or Dominican, and lived in areas in Northern Manhattan or the South Bronx that are predominantly low income. Over the course of two days during their third trimester, they wore a small backpack equipped to extensively sample the surrounding air; at night they placed it near their bed.

Children of women exposed to high levels of PAH during pregnancy were nearly twice as likely (1.79 times) to be obese at age 5, and more than twice as likely (2.26 times) to be obese at age 7, compared with children of mothers with lower levels of exposure. The 7-year-olds whose mothers were in the highest exposure group had, on average, 2.4 lbs. more fat mass than children of mothers with the least exposure.

"Not only was their body mass higher, but it was higher due to body fat rather than bone or muscle mass," says Dr. Rundle.

These findings fit with evidence from animal studies and tissue sample experiments. Mouse studies have shown that exposure to PAH causes gains in fat mass, while cell culture studies have shown that exposures to PAH prevent normal lipolysis, the process by which fat cells shed lipids and shrink in size.

Previous research at the Columbia Center for Children's Environmental Health (CCCEH) at the Mailman School found that prenatal exposure to PAH can negatively affect childhood IQs and is linked to anxiety, depression and attention problems in young children. PAH also disrupt the body's endocrine system and are known carcinogens.

Fortunately, there are ways to reduce PAH exposure. Some fuels release more of the chemicals than others, explains Dr. Rundle, and efforts in New York City to take diesel buses off the streets and retrofit oil furnaces so they burn cleaner fuel is already starting to help.

Despite known linkages between socioeconomic status and obesity levels, the researchers found the impact of PAH on risk of obesity was not influenced by household income or neighborhood poverty. They also ruled out the influence of cigarette smoke in the household and proximity to highly trafficked roads.

Robin Whyatt, DrPH, the paper's senior author, notes that the study is one of the first to present evidence that chemicals in the environmental can contribute to obesity in human beings. Future research will focus on identifying other examples of these "obesogens" and ways to reduce them, says Dr. Whyatt, who is deputy director at CCCEH and professor of clinical environmental health sciences at the Mailman School.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our obesity / weight loss / fitness section for the latest news on this subject. Funding was provided by a grant from the National Institute of Environmental Health Sciences (NIEHS) (# P01 ES009600).
Columbia University's Mailman School of Public Health Please use one of the following formats to quote this article in your essay, paper or report:

MLA

Columbia University's Mailman School of Public Hea. "Clinical Evidence That An Environmental Pollutant Can Contribute To Obesity Through Prenatal Exposure." Medical News Today. MediLexicon, Intl., 18 Apr. 2012. Web.
22 Apr. 2012. APA
Columbia University's Mailman School of Public Hea. (2012, April 18). "Clinical Evidence That An Environmental Pollutant Can Contribute To Obesity Through Prenatal Exposure." Medical News Today. Retrieved from
http://www.medicalnewstoday.com/releases/244184.php.

Please note: If no author information is provided, the source is cited instead.


' Clinical Evidence That An Environmental Pollutant Can Contribute To Obesity Through Prenatal Exposure'

Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.




View the original article here



No comments:

Post a Comment