Expose the fetus to plant estrogens can lead to infertility in women

Main category: fertility
Also included in: pregnancy and obstetrics;  The women's health and Gynecology
Article Date: 04 may 2012-0: 00 PDT

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An article published in the documents-in-press of reproductive biology describes the effects of prenatal exposure short to plant estrogens on the oviduct of the mouse, the effects of the formula for baby at base of soybean on modeling human infants. The results suggest that the exposure to chemical estrogen in the uterus or in childhood have the potential to affect the fertility of an adult woman, possibly to provide the mechanical basis for certain cases of unexplained female infertility.

Previous research suggests that exposure plants estrogen or other environmental estrogens (synthetic substances with the same way to the estrogen produced naturally in the body) may have effects in the long term the adult female reproductive health. Wendy n. Jefferson, a researcher in the laboratory of Carmen j. Williams in the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, has already demonstrated that the results of genistein plant estrogen exposure neonatal sterility full adult female mice. Causes of infertility included failure to ovulate, reduced the ability of the oviduct to support the development of the embryo before implantation and uterine rupture in support of the effective implementation of the embryos to the blastocyst stage.

The team now reports that neonatal exposure to genistein alters the level of the response immune in the mouse oviduct, called mucosal immune response. Some of the genes of the immune response have been changed from the time of the treatment of genistein, while others were later amended, when the mouse is in early pregnancy. Together, these changes led to altered immune responses compromise support oviduct for the development of the preimplantation embryo, which would probably contribute to infertility.

These findings raise the possibility that exposure to low levels of the environment or plant estrogens during windows sensitive development can change the balance of the mucosal immune response in the uterus and the oviduct.

In mice, the development window in which these changes occur is found only in the neonatal period; in humans, the genital development continues at the beginning of puberty. Estrogenic chemical products exposure to the fetus of female, baby, child and adolescent have potential impacts on the immunity of mucous membranes of the reproductive tract and, consequently, on the fertility of the adult. The authors present considers that to mitigate these risks, including minimising the use of soy-based baby formula, is a step towards the maintenance of women's reproductive health.

Article adapted by Medical News Today news release original. Click on "References" tab over the source.
Visit our section of fertility for the latest news on this subject. Jefferson WN, Padilla-banks E, Phelps JY, Cantor AM, Williams CJ. Neonatal phytoestrogen exposure changes the response immune mucosal oviduct pregnancy and affects the development of preimplantation mouse embryo. Biol Reprod 2012; (in press). Published online before print may 2, 2012; DOI 10.1095/biolreprod.112.099846.
See also: Jefferson WN, Padilla-banks E, Phelps JY, KE Gerrish, Williams CJ. Posteriorization permanent oviduct after neonatal exposure to the phytoestrogen genistein. About Health Perspect 2011; 119: 1575-1582.
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